Right now the change is that you cannot download newly published books with the old Kindle desktop apps. If you have an E-ink Kindle, you can still (for most books) use the "download & transfer via usb" option on the website to get copies of your purchased books which you can decrypt.
There are no changes for sideloading to a Kindle. There are some changes for emailing books to your Kindle. I'll let others fill in the details on that as I haven't really looked into it.
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