NO! (at least the way you describe).
Calibre is the Program that manages Libraries.
'the list' is A LIBRARY. (and the under laying folders that belong)
You can have as many Libraries (Create/ Switch) as you have disk for,
BUT
The folders (books) can only serve ONE Library. Same book in 2 Libraries = 2 copies.
Create a New Library (right click the Library Icon: Create/Switch) in a new location (DO NOT attempt to overlap an existing Library): The name can be anything. Mine is 'Main' (I also have 'Intake2', Juvenal, Magazines ).
The latter is because the structure of (custom) columns/settings is different from Main. Juvenal is a Library that is child safe
.
In the Old Library (typ Calibre_Library), Move books to the new Library (ies) by right clicking on the selections: Copy to Library:<target>. Switch there and make adjustments. Switch back.
Repeat