Kindles do not use ePub books. If transferring directly from Calibre to a Kindle, the book must be in a format the Kindle uses.
If you are emailing a book through Amazon, you can use ePub, because Amazon will change/convert the format to one the Kindle can use. For this process to work, the email address you are sending FROM needs to be listed on your Amazon account to be an accepted email address. You do that in the Content & Devices area on your Amazon Account, under Preferences...Personal Document Settings. Add any email address you will use to send books to Kindle using email.
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