I definitely second Alas, Babylon; On the Beach; and Lucifer's Hammer. Three very different books and two very different takes on a nuclear holocaust.
In addition I'd reccomend:
The Postman by David Brin (Don't let the Kevin Costner movie fool you, apples and oranges)
Earth Abides by George R. Stewart
The Stand by Stephen King
The Road by Cormac McCarthy
I've enjoyed all of them, and they are all very unique takes on the end of the world, some hopeful, some not.
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