Hitch could take your content and make it a regular reflowable epub2 for upload to Amazon and almost everywhere else. It will then work in some fashion on everything and a two page spread source image can be a single image to nearly fit a screen in landscape device mode if supported, though images will be a bit small on a 4.3" phone or 5" eink in portrait.
Many apps can do landscape and some really old kindles do rotation automatically. Some apps and eink devices only do portrait.
Download the 87p Beatrix Potter and compare it on phone, eink and tablet.
Google Playstore has some free Teenage Mutant Ninja Turtle comics which sort of work in Google Play books on a 6.8" eink, but of course are better on a 10" tablet.
Smashwords (now part of D2D) redistribute to Apple, Barnes & Noble, Kobo, Tolino, Scribd etc. Via reflowable epub, or poorer quality from MS Doc.
Amazon KDP works best with reflowable epub upload.
Google Playstore Books works best with reflowable epub.
With 3 uploads using reflowable epub2 you access phones, Fire, Tablets, apps, eInk; almost 100% of the Market and probably every eink based ereader in the last 12 years (some older that that are still going and most of those can work with epub or Mobi via epub2 uploaded to Amazon KDP).
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