Kindles use a proprietary fixed-layout for comics in either KF8 or KFX format, depending on the target device. That enables features like full screen and panel-by-panel viewing. A conversion from EPUB to MOBI via calibre isn’t going to generate the correct format.
Your best bet is to extract the images from the EPUB, create a CBZ or CBR, and use Kindle Comic Converter to produce a proper Kindle file from that.
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