Adobe Digital Editions for handheld devices is currently available on the Sony PRS-505 and PRS-700, but will soon be available on several other EInk devices. It requires the ePub to be split into manageable chunks, which are typically chapters. If a chapter is very long it may require multiple files per chapter. The easiest way to handle this is to run your document through Calibre, which will add PRS-505 specific processing if you ask for it. This includes chapter splitting and other work-arounds. Note that the input can be ePub if you like (or HTML or whatever), and you can always explode the resulting ePub and apply your own customization afterwards if you want.
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