@arguendo - to activate the main Apply button you must hit the Apply changes to this tweak button for the individual settings you change.
Never change anything in the calibre installation folder (e.g. C:\Program Files\Calibre2),
If it is a permissions problem it will be in the Configuration folder, which I doubt, you can open via the Preferences>Miscellaneous->Open calibre configuration folder button. If you can open files there with a text editor then it ain't a permissions problem.
BR
Last edited by BetterRed; 03-15-2022 at 05:52 PM.
Reason: added a screen shot
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