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Years ago, WACOM graphics Tablets caused grief.
It sure would be nice if we could narrow this down, by figuring What is different (or changes from one use to another)
Most common is Multi Monitor rigs, with dialog opening off visible areas
Hi DPI graphics,
Aggressive A/V (defender seems solid, so why spend $). Calibre uses background 'worker' processes, so things don't go All Stop, while they grind away.
3rd party 'helper tools' can get in the way
Calibre works pretty much straight up on all my (mostly Vanilla) Windows systems.
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