The drain is basically 99.9% unrelated to anything KOReader might do (because that's essentially nothing in the grand scheme of things ;p), so usage patterns ought to be fairly irrelevant (unless you spend your time scrolling in a PDF ;p).
The only thing that ought to matter are the frontlight & Wi-Fi.
BT being off is not actually a thing that you can do while WiFi is on right now, given the hardware/kernel constraints, but (hopefully), the WiFi+BT chip might actually be the thing with the sanest power management in there (and, again, Nickel's in the same boat there) ;p.
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