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I am lefty as well and actually like the button layout. I find that most often I am holding the reader by the lower left and right middle... I use the page turn button on the lower left hand side most often and feel the layout is quite good (at least for me). I find holding this is actually more comfortable than a pbook. My hands would tend to cramp and numb reading a paperback due to carpal tunnel. YMMV...
RA
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