I pretty much do what
Sirtel does when I create or modify a book. For the rest I just rely on the plugboards in Calibre, it does fix the majority of them.
For me I copy synopsis to a text file to make the changes then its copied to the epub metadata. In the Calibre html it makes it into 1 paragraph. On my kobo it works with a manual sideload, Calibre 5.27 (with kobotouchextended and plugboards mod), and with Calibre 4.23 (with all standard settings and plugins).
This does annoys me a lot

but ahh well what can you do....
This is what I put into the epub metadata
Code:
blah blah with space below.<br/><br/>blah blah no space below.<br/>blah blah.
When the epub is added to Calibre, it looks like this.
Code:
<div><p>blah blah with space below.<br><br>blah blah no space below.<br>blah blah.</p></div>