I finally found a way to overcome this. I let windows compatibility tester test and set it to run in compatibility mode for windows 8 .Now it starts and runs regardless of whether any VPN is running. I had earlier taken your advice and changed VPN providers to no avail as I kept getting the same error codes.
RROR: Contacting calibre failed: Failed to contact running instance of calibre, try restarting calibre
Failed to connect to Listener at: \\.\pipe\CalibreGUI-Johnx with error: QLocalSocket::connectToServer: Invalid name
b'launched:["calibre.exe"]'
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