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Feel free to bundle pip with your plugin and use it to install your dependencies.
Just add the location you ask it to install to, to sys.path and you should be fine, assuming of course the incompatibilities between compilers versions used to build the native dependencies and the python calibreuses dont causes issues.
In my experience python package management tools are all very poorly designed and extremely fragile, so I am not going to take on the responsibility for them in calibre.
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