I voted no mostly as a practical/realistic answer rather than an absolute one. My phone is too small to read on comfortably (in comparison to my e-ink reader), my desktop computer screens are not comfortable for relaxing at while reading narrative text (I have recently read an entire non-fiction book on them, but only one chapter in a sitting). My laptop is far too heavy and awkward to sit back and read a novel on. I do have a tablet-like-device but it's screen quality is not the best and it's still heavier, shorter of battery life and awkward to use one-handed.
I suspect a comfortable LCD solution is possible - if it was designed like an e-ink reader at a size and with a user interface appropriate to the purpose - but then it would likely compare unfavourably to existing e-ink solutions because of its shorter battery life.
I tend to think of it a bit like comparing a paperback novel to a large format paper magazine. Yes it is possible to read a novel published in magazine format, but it's far less comfortable and convenient than the smaller paperback form. But there are still plenty of things that work better in the large glossy format of a magazine - so I'll have both my e-ink and my LCD devices, thank you very much.
