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For a print edition, upload a right-sized, error-free PDF, with any images at 300 dots per inch. To look like a trade paperback, choose 5.5x8.5 inches if it's under 300 pages, though you might go to 6x9 if it's longer. 12 point type is best; 11 point if you're really trying to squeeze. (This isn't a mass-market paperback on a revolving rack at the drugstore!)
Choose mirrored pages, margins a minimum of 0.5 inch on the three outside edges, with a gutter (inside edge) 0.8 - 1.0 inch depending on the number of pages from 100 to 400. Spend a LOT of time getting it right. You can do this in Word, though I actually prefer OpenOffice Writer for the final tweaking and outputting the PDF.
I don't use headers, so as to avoid the tradition (which I respect) that there should be no headers or footers on any page in the front matter, that begins a chapter, or that is blank or has a full-page image. Rather I center the page number in the footer, which falls outside the bottom margin, but 0.5 inch is enough to avoid trespassing on the no-go zone.
Get a physical proof copy if you possibly can and spend a LOT of time examining it.
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