Just to be picky: I doubt whether Asimov (or probably any of the others) would have been astounded at the idea of using multiple fonts. When manuscripts are hand or type written there is a much stronger demarcation between the writing and layout. They might have been astounded that a publisher would bother, but not by the idea of it.
Now that it's possible to publish almost as soon as the words slide out from under the caret, there can be a temptation to layout as you go. I doubt that is a temptation felt by only me; I think it is a temptation instilled by the use of WYSIWYG editors that have put layout in the hands of amateurs for so long now that it's hard to shake that sense of responsibility and the desire to see what will be the end-result as soon as possible. Instant gratification.
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