With Kobo, you can download books from the store. For DRM free books, they will be downloaded directly. For books with DRM, they are downloaded via ADE.
It might be different for comic. Some are available as epubs or possibly PDF. But, I think there are some that can only be viewed in iOS or Android apps. I don't read them so I haven't really looked. The format available is shown at the bottom of the page for the book. The format and whether it has DRM is shown under "eBook Details". Then there is a list of devices that the books can be read on. If it includes "eREADER", then you will be able to download the book. If that is missing, it probably isn't, but, it has been a while since I have seen any discussion on this.
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