same issue
I have the same issue, Calibre won't start.
Everything I have gathered so far,
-It launches in Safe Mode just fine.
-I have disabled all startup programs in Task Manager but it still doesn't launch.
-Calibre 32-bit also doesn't launch, nor does Calibre Portable.
I will also say that whatever the problem is, it could have only occurred by itself as it worked fine when I turned my computer on and launched it this morning(12 hours ago). It launched just fine and I wrote some metadata for some books and then left for work. When I came back from work and I tried to open a book it wouldn't and so I tried restarting the program and it wouldn't launch, thus starting my troubleshooting process.
Debug:
calibre 5.12 [64bit] embedded-python: True is64bit: True
Windows-10-10.0.19041 Windows ('64bit', 'WindowsPE')
('Windows', '10', '10.0.19041')
Python 3.8.5
Windows: ('10', '10.0.19041', '', 'Multiprocessor Free')
Interface language: None
Successfully initialized third party plugins: Count Pages (1, 11, 0) && FanFicFare (4, 0, 2) && Generate Cover (2, 0, 2) && Kindle Collections (1, 7, 29)
Turning on automatic hidpi scaling
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