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Originally Posted by deb27
OK....this problem isn't actually solved. Apparently restarting my computer in Safe mode and then restarting it normally (without actually changing any of the start up features) fixes the problem temporarily. I've tried turning off everything in Bit Defender but that hasn't helped. I've given up. Maybe someday someone will come up with a solution. I'm out of ideas. And no, I'm not going to switch AV's. That's a lot of time, effort and money with no guarantee that it'll work.
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It's actually no money at all to switch to a good AV. You can switch to Windows Defender for no money as it is included with Windows.
Try turning off Bit Defender and install the current version of Calibre and see what happens. Also, see if there is an update to your video car driver.
If you are running a laptop with dual video, run Calibre using the other video chip and see if it works.
Thing is, something is wrong with your system. It could be something you run at start. So disable one program at a time and keep trying Calibre. If you find Calibre works, then you'll know what not to run at start.