I do daily backups of our computers to a local RAID NAS using Acronis TrueImage. Most files on our computers are copied hourly to the cloud using LiveDrive (paid), which has never caused a locking/write/corruption problem. In addition my library and some other stuff is copied to Dropbox. Because the three have different versioning strategies I have used all of of them to recover individual files. Luckily I could recover from the NAS after most my various disk 'failures' (caused by hardware and stupidity), which is much faster than downloading from the cloud. Only once have I had to do a large recovery from LiveDrive, which worked but was painful.
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