Upgraded a laptop (without re-install), a spare test one, to Linux Mint 20.1, Calibre 5.11 and Alf's DeDRM 7.0.3.
Only issue was a printer and scanner reappearing every time it was deleted. Edited cups.conf and disabled the auto-discovery service.
All our Amazon Kindle azw3 Paperwhite 3 ebooks were OK. First time I forgot to enter the Kindle serial number. They all loaded, inc covers and metadata, but still with DRM. So deleted them, added serial number and imported again.
The only plugin I use out of 29 that wouldn't install on 5.11 was FictionDB.
No doubt the DeDRM is still beta as it doesn't do all of 6.x. There was a bug with PDFs found that's going to be back ported to 6.x, apparently some PDFs are non-standard.