I search for multiple spaces (replace with one), lines starting or ending in space (delete space) and empty lines (delete) all as the LAST thing after all other edits. Then I save as in native and then docx for Calibre.
I only use non-standard width spaces for paper versions (like between a number and the unit abbreviation). I'd rarely use a non breaking space (either ctrl or alt space, I forget). I do sometimes have an non-paragraph return, but NEVER EVER on fully justified text.
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