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That is what Tagging is about. Tag with GOOD subjects when adding (and ditch the 47 subject homonyms many Authors load the OPF with)
Multiple tags was a holdover from PAPER Card Catalogs (remember those) that needed cross referencing .
eg. Calibre can find any tag with Werewolf, no matter what combination it is with.
Clean your tags up. Calibre can help
For example: I use the
Tag mapper to clean up the 42 different ways Science Fiction was coded.
Or just use
Manage Tags: and fix/remove the obvious as you scroll.
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remember your 'fixes' are not automatically embedded into the books. If you are in the habit of using the OS to copy: Use one of the other tools to force the BOOKS to update.