Did you upload that calibre-64bit-5.10.1.msi to VT?
I just uploaded the calibre-64bit-5.10.1.msi I got from github this morning, and I got this from VT ==>>
https://www.virustotal.com/gui/file/...c1797/behavior
Nothing written to Windows only user Local\Temp
Note - I didn't get the Microsoft Sysinternals Sysmon option (the one your link goes to), I only got the VirusTotal Jujubox option. I have no idea why.
The only malware I've had in a decade came with Piriform's CCleaner soon AFTER it was bought by Avast, VT didn't find it, MS Defender found it. And it wasn't a false alarm, the CEO of Avast published a mea-culpa - speculation was it was put there by a disgruntled Piriform exec who didn't get to keep their job.
BTW check out the Registry Keys opened (there's a down arrow expander) - 300 of the beggars
BR