Can you try telling your AntiVirus/Defender software to leave PageEdit and its pieces alone?
If Sigil 1.4.3 runs and works, the problem can not be Qt related at all as PageEdit uses the exact same Qt version as Sigil and does not use the Python parts at all.
There is no sound technical reason PageEdit can not run if Sigil can run so I think the issues must be system/AV related?
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