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@TdeM - did you try using the same shortcut sequence (Ctrl+Shift+2) in another program's shortcuts.
I had a problem with Shift+D in calibre, but then I discovered I had also had problem with it in other programs. So instead of using Shift+D to open DOCX files I use Shift+W.
Interestingly the issue went away of its own accord, but I don't know exactly when. My guess is that a 3rd party start-up applet was grabbing Shift+D, and the blunder was rectified in a subsequent update.
BR
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