Nightmode has no impact on battery life (if anything, it should require a tiny bit more processing power, but it's noise in the grand scheme of things).
I don't know how Nickel sets up the Aura One, but Mk. 5 devices run with an hilariously broken CPU scheduling setup in Nickel. That's the only significant long-term power consumption difference I can think of.
(If you forget about Wi-Fi, which is the n°1 drain, Nickel or KOReader).
Other than that, unless you spend your time opening new books, we should be eating noticeably less CPU time for standard reading activities. But that shouldn't make a significant difference on battery usage (some, though).
The other thing to remember is that the battery gauge means almost nothing on Kobo devices. It's notoriously hilariously unreliable.
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