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Slowdowns are typically attributed to having Preview open when huge html files with very few line endings in them (and perhaps lots of images) are open in Code View. Normal epubs with many reasonably-sized html files (<300kb) perform best.
What version of Sigil were you using before 1.4.3? Just curious, because there shouldn't really be any noticeably performance changes from version 1.3.0 to now. Qt is leaving older hardware behind (faster and faster) in general, but even so, I don't get any of the "not responding" messages or severe slowdowns you describe even on my very underwhelming (and aging) Inspiron laptop.
The fact that you're using the same AV as before Sigil 1.4.3 isn't all that relevant since Sigil 1.4.3 isn't the same binary running the same code as earlier versions. Nor is Windows 10 itself the same--assuming you've not disabled mandatory updates. You should definitely try exempting Sigil (and its various folders) from your AV. And to be perfectly honest: I don't think it's necessary (or wise from a performance standpoint) to run real-time scanning AV software in addition to what comes built into Windows 10. Simultaneous real-time AV file-scanning processes are a recipe for disaster in my book.
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