Got my M1 Mac mini (16GB Ram, 1TB SSD) Nov 25 and Calibre works fine. I haven't found anything that doesn't work properly. Performance is fine--maybe just slightly better than my 2018 Mac mini with core-i7, 512GB SSD and 64GB ram.
For benchmarking, I converted Follett's Fall of Giants to kfx and compared the performance to that of the 2018 Mac mini:
kfx conversion 2018 Mac mini: 107 seconds
kfx conversion 2020 M1 Mac mini: 100 seconds
I use a number of plugins, not problems. I also have my own Python programs that access the calibre database remotely to grab information using calibredb and it all works perfectly.
Given the massive change to the hardware on the M1 devices, Apple has been very successful making almost everything compatible without compromising performance.
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