I always used my Nokia 770 (4.1" screen) in landscape mode, but have never needed to do this with 6" EInk screens. With a 5" screen I might want to switch to landscape, but to me the major issue would be control over line spacing and margins. The smaller the screen the more important this is. If you are willing to live with (or, better yet, prefer) small line spacing and margins a 5" screen will display more text per page than a Kindle 1.
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