If Ctrl+r and Shift+Ctrl+r are okay in Safe mode but not in Normal mode, that suggests to me that is there something running in Normal mode, that is not running in Safe mode. Something that acts on, but doesn't consume the key sequences.
You can get a list of current processes as a CSV via the command line or powershell ==>>
Windows Tip: 3 Ways to Print A List of Running Processes
BR