Not on eink.
If you are not on eink, a real app is hardly any more time to build and can be on Apple, Amazon, Google and other stores as well as versions for Mac OS, Windows and Linux laptops / tabletish things.
https://en.wikipedia.org/wiki/EPUB#Version_3.0.1
epub3 is nearly ten years old.
Code an app
today rather than waiting for some epub3 app that will not be on all platforms and won't support multimedia on eink. Few eink ereaders have sound. Fewer have colour (which is poor and makes the text poorer contrast) and none sensibly do video.
It's not book like HTML, but paginated Multimedia (if it has pages). Books have pages. Scrolls are not books. If you have what you want on a website today it could be an app by next week on all platforms except eink.