Originally Posted by SysopChris
calibre folders
C:\Program Files\Calibre2
D:\Users\SysopChris\AppData\Roaming\calibre
This is commonly known as the Calibre Configuration directory, it contains all the global Preference settings. Its location can be set via the CALIBRE_CONFIG_DIRECTORY Environment Variable. You don't want to lose this - include it in your data backup regime.
D:\Users\SysopChris\AppData\Local\calibre-cache
This is commonly known as the Calibre Cache directory, it's used to stash stuff to improve performance (images, recent books etc). Its location can be set via the CALIBRE_CACHE_DIRECTORY Environment Variable. It will be created as needed, so no need to backup
D:\Users\SysopChris\AppData\Local\calibre-ebook.com
D:\Users\SysopChris\AppData\Local\calibre-parallel
Those two seem to have something to do with the Qt webengine component used by the Viewer, Editor etc. You probably have a D:\Users\SysopChris\AppData\Local\cache directory too, it also seems to be Qt related (google "qt shader cache").
These can probably be deleted, and let QT create them as it needs them.
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