One of the top benefits of digital books is the ability of the reader being able to set fonts etc. in a way that makes their reading experience the best it can be. Users with vision issues are a prime example. There are a multitude of vision issues and a multitude of what works for those users.
What works for you may not work for me, and so on. Locking out user input is a mistake of the largest kind. It was that ability of the user, me, to make changes to the font face, size, and line spacing, that prompted me to try a Kindle in the first place. It is also what made me a convert to e-books. It gave reading back to me.
Any author or publisher that opted to force their settings on me in a book is an author/publisher I would avoid. Especially if those settings couldn't be overruled using Calibre.
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