Never have the window behind the screen, also it's not great behind you. Be at right angles or fit blinds or curtains.
Unconscious changing of focus distance caused by movement causes headaches. If you don't need glasses, or have properly selected glasses, there is no need to look into the distance.
Make sure the keyboard is near the edge of the desk and you are close to it so that the screen is at your most comfortable reading distance to read a novel for hours.
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