@Alanon: For Joe Random on current FW versions and forgetting extreme corner-cases, if you follow the recommended syntax (and minimum supported versions, if applicable), not really.
I like not depending on Nickel because I don't actually run Nickel most of the time, hence KFMon

. But NM is definitely more user-friendly while inside Nickel, hence the KFMon generator for the "best of both worlds" approach (i.e., an NM button, but launch handled by KFMon. This is what the OCP bundles do.).