If You are talking about something like this:
https://texdoc.net/texmf-dist/doc/la.../microtype.pdf
I don't know when it will be possible. But after many years colour is coming (let's hope) so also microtypography for erader one day could come.
Until now Epub2 - Epub3 and their implementation in ereader are far from the perfection of Latex (and do it once, in a physical page - pdf is like a phisical page - is much easier).