i do run malwarebytes, have done for years. if that is installed correctly it will not mess with calibre
So between us we are asserting the Malwarebytes + Windows defender + calibre + calibre portable should all happily co-exist
but anyway, a simple 1st test is to boot the PC in safe mode & see if calibre starts ok then.
then, as asked in #4 we need to know where the databases ( main version and portable version) are. and do the folders look OK i.e. can you see author subfolders and you see metadata.db in both
it is possible that CCleaner did something bad before you removed it e.g. if you let it "clean" the registry ( never a good move)
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