[DNSB]

I despise using drop caps since they basically need to be tweaked for every format and ereader. That being said, the larger the font size for a drop cap compared to the body text, the harder it is to to make it look half decent on multiple platforms. One book I worked on used a cursive font for the drop caps. I ended up with a separate class for each letter used as a drop cap and another class for the case where a double quote preceded the first letter. It ended up looking half decent on 768x1024 or larger displays but the CSS was a dog's breakfast.

The basic code looks like this with the margins being tweaked for the individual characters:

.first-letter-t {
float: left;
font-size: 300%;
margin-left: 0.03em;
margin-top: -0.3em;
margin-right: 0.12em;
margin-bottom: -0.36em;
font-weight: bold;
}