Thanks Bernie. My issue does not seem to be addressed by the FAQ other than a blanket NAS is bad. I agree having the database on the NAS isn't great and that is why I am trying to move it.
However, the pattern of requiring the media files to live on the actual device doesn't make sense to me. I've used my NAS as my primary media storage (RAID 0, configured to backup off-site) with LazyLibrarian and Calibre for years. It is only recently that I've begun to consolidate config locations and permissions. I don't have any of the issues listed in the FAQ. The only thing I want to do is move the location metadata.db and config directories, as indicated by this doc:
https://manual.calibre-ebook.com/customize.html
There should be no reason why Calibre can't read the database locally and reference shared directories for the files like any other media management software (Radarr, Sonarr, Plex, etc.). It is inconceivable that managing three dozen 1mb *.epub and associated metadata (which doesn't change) is so taxing that it can't compete with on-the-fly 1080p transcoding of a 10gb video off the same share and sharing paradigm. What am I missing here?