You can use the Modify ePub plugin to strip the metadata back to Dublin Core elements - i.e. those prefixed by dc:.
The Sigil ePub editor has a GUI tool to add, change, delete metadata items within the embedded .opf, being a minimalist I use it to remove dc:description and dc:subjects.
Beyond that you can edit the embedded .opf with a text editor or one of the ePub editors. Or you can write, or hack an existing, plugin to meet your specific wants.
Take care
BR
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