I feel guilty getting in early with nominations because I am still lagging behind back at
Doctor Zhivago 
but these are books I have previously considered for reading and so came readily to mind. Mine are:
Doomsday Book - Connie Willis
https://en.wikipedia.org/wiki/Doomsday_Book_(novel)
https://www.goodreads.com/book/show/24983.Doomsday_Book
https://web.archive.org/web/20080521...0/classic.html
The Plague Dogs - Richard Adams
https://en.wikipedia.org/wiki/The_Plague_Dogs
https://www.goodreads.com/book/show/...he_Plague_Dogs
Blindness - José Saramago
https://en.wikipedia.org/wiki/Blindness_(novel)
https://www.goodreads.com/book/show/40495148-blindness
Doomsday Book is a long shot, but is long and seems people either love it or hate it.
The Plague Dogs is on my reread list, not a great literary example but has survived time.
If those who have mentioned them already, or anyone else, were to nominate
The Andromeda Strain and
Love in the Time of Cholera I would do backward flips with excitement
.