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I think there are typos and then there are typos. Say letters are transposed in a word--well, stuff happens. That's different from misuse of homophones--like discrete for discreet, or defuse for diffuse--especially if it happens more than once, which indicates to me that the author/proofreader was oblivious to the misuse. (I once read a book wherein characters kept sitting on their hunches around a campfire.)
I also consider continuity errors as more than simple typos. Characters with changing eye color, timeline screw-ups, etc.--those mistakes indicate sloppiness.
So when people say ten typos are too many--it depends. I can easily forgive ten discrete misspellings in a 300-pp. book; I would be furious at ten continuity errors and send nasty letters.
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