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Copy & paste the PowerPoint slide by slide into Word or LibreOffice Writer. Adjust any images. Adjust format of text with styles.
Save docx (or Save As in Writer).
Import Docx to Calibre.
PDFs are an envelope with instructions and data to create a proof copy of a paper printed document and also to print independently of the printer features (assuming page size is possible).
PDFs are a terrible source for epubs. They can have any mix of instructions, vector images, bitmap images and text and define a fixed layout. So two different PDFs will not work the same for conversion.
Sometimes you can import a PDF to a program and then fix it up a bit and export as something else.
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