Perfect viewer setup guide:
Long Press Settings: Just has regal refresh enabled for greyscale images (disable for color images), we do contrast optimization in app. (The contrast adjustment slider could be used in addition, depending on content (usually doesnt have to be used)). Also has a short animation filtering delay - not sure if I'll keep that, still testing (this will delay screen transitions after any touch action. You normally use it to filter out screen transition animations in apps, where you cant disable them).
Touchscreen settings (one touch) - first enable the more complex touch layout (first touch layout, not third) in settings:
(There is a reason for this strange layout, and it is usability - while reading. You will hold the eReader slightly different (different hands, different hand positions) over time and still would want access to the most important functions. With both hands. And without worrying about missclicks. I very much recommend setting it up somewhat like this.

)
General settings for most comics:
Contrast (actually Hue/Saturation/lightness) adjustments (use both saturation and lightness settings as seen) - this is the reason for why images are displayed blue in the screencaptures, on device they will be grayscale (because of the eink screen) - blue is the highest RGB value, so shifting images to more monochrome blue using the lightness setting, also increases contrast.
This is still the most ideal contrast configuration I've found, without reducing detail (if you increase lets say gamma, or Boyues system contrast you will sacrifice dark detail.
Sharpness adjustment:

Enable or disable depending on content. Move slider depending on content. This also interacts with Image smooth filter: Nearest neighbor/Averaging/... (Averaging is default), so tinker with both until satisfied. (Depending on content) Note that in my case it is turned off with Nearest neighbor smoothing enabled. Try that first.
Crop pages set to automatic crop:
Frontlight settings:
9 pips of warm LED
Adjust blue LED to room conditions (about half to -2 pips from black), so the image becomes roughly neutral white looking.