The op has still not said if it's a network drive or not.
But continuing with the idle speculation that it is... Windows can lose such drives sometimes. E.g. I have two Nvidia shield drives mapped to drive letters on my pc for file copying. Two different devices. Occasionally one or both stop working , in that windows reports it cannot reach them, for which I blame updates or glitches on the shields. Reliability depends on what is actually hosting the drive and how it is accessed from the pc, and most obviously if that device has not been accidentally switched off!
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