This time (just finished viewing on the other PC). It also took quite a bit to pop this message.
Code:
calibre, version 4.10.1
ERROR: Error: Error communicating with device
IOError: disk I/O error
Traceback (most recent call last):
File "site-packages\calibre\gui2\device.py", line 90, in run
File "site-packages\calibre\gui2\device.py", line 513, in _books
File "site-packages\calibre\devices\kobo\driver.py", line 1938, in books
File "c:\t\t\apsw-k8s6ukkv\src\cursor.c", line 236, in resetcursor
IOError: IOError: disk I/O error

It does not like being on a USB3 port in any way (I have a USB3 Hub that has both 2 and 3 ports)