Assuming the following is the graphic novel in question, guided view does work on e-ink.
https://www.amazon.com/dp/B00A820U0A/
Note, this may need to be downloaded directly to the Kindle over the internet (as kfx). I seem to recall some comic-related controls not working properly with download and transfer via USB (azw).
Also, double tapping for guided view, it still displays the full page first and then if you go to next, it will display individual panels.