Hi Shaun!
If you're talking about the home screen, it is possible. Go to "settings" and "beta features". Selecting "large print mode" gives you a font scale slider. With mine set to 140% the home screen show the three most recently opened books, and the stacked thumbnails below them ("My Books" etc.) obediently disappear. I like the simpler look for the Home Screen that this produces.
And while the large print setting increases the font size across the user interface, any individual collection still displays eight thumbnails per page in cover view. So I don't know how to change THAT particular behavior.
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